Correlation of Anti-HLA IgA Alloantibodies and Fc Receptor Motives with Kidney Allograft Survival

Immunoglobulin A (IgA) is the most abundant antibody isotype in humans and anti-HLA IgA was found sera of transplant recipients. Focusing on patients awaiting kidney re-transplantation, we tested impact anti-HLA-class I/II antibodies graft survival. We analyzed 276 with 238 without allograft failure. Eight motives Fcα receptor (FCAR) Fcγ were The distribution IgA1/A2 IgG differed significantly (p < 0.0001) between both patient groups, IgA1 plus IgA2 more Allograft survival impaired if I II present, first 105 months (9 years) follow-up (median 43 vs. >105 months, p = 0.007). Patients only had a shorter within that period (88 0.008). Moreover, 0.02) carriers GG AA + AG genotypes FCAR rs16986050. Thus, presence associated may